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3.1(T)
THIRD YEAR B. PHARM
PHARMACEUTICAL JURISPRUDENCE (THEORY)
Minimum 50 Hrs./Yr
1.
Legislation to regulate profession of Pharmacy. The
Pharmacy Act. 1948.
(5)
2
Legislation to regulate the importa, manufacture,
distribution and sale of drugs.Drug and Cosmetics Act.
1950 and Ruls 1945 and amendments there of.
(15)
3.
Legislation to control the advertisements,
excise-duty and prices of drugs.
(5)
a)
The Drugs and Magic Remedies (objectionable
Advertisments) Act 1954.
b)
Medicinal & Toilet Preparations Excise Duty
Act. 1955.
c)
Drug Prices and Control Order 1979.
4.
Legislation to control the operations to Dangerous
Drugs. (6)
a)
Dangerous Drugs Act 1930.
b)
Poisons Act 1919.
c)
Opium Act 1978.
5.
Legislation affecting pharmaceutical & food
industry.
(4)
a) Industries
(Development & Regulations ) Act. 1951.
b)
Prevention of Food Adulteration Act 1954.
c)
Shops Establishment Act of Maharashtra State
6.
Miscellaneous Acts
(5)
a)
Consumer Protection Act.
b)
Prevention of Cruelty to Animals Act.
c)
Insecticides Act.
d)
Code of Pharmaceutical Ethics framed by Pharmacy
Council of India.
7.
Introduction to various drug regulatory authorities
vis., FDA, WHO, ISO.
(5)
8
Introdution to Indian Patent Regulations, WTO and
FDA, Drug Import Export Policy.
RECOMMENED
BOOKS :
Latest
editions of the following books.
1)
Mithal B.M. ‘Text Book of Forensic Pharmacy’ ,
7th ed,
National
Book Centure, Caculta, 1985.
2)
Jain N.K., ‘A Text Book of Forensic Pharmacy
(Pharmaceutical
Jurisprudence)’, Vallabh Prakashan, Pune, 1989.
3)
Kuchekar B.S. & Khandatare A.M., Forensic Phamacy including
Industrial
and Labour
Laws. Nirali
Pharmacy Council of India
4)
‘Code of Pharmaceutical Ethics’, Pharmacy
Council of
India
(P.
B. No. 337),
New Delhi
Year.
5)
Current Government of India Publication of all
Drugs Acts and Rules.
6)
Bharti, ‘Manual of Drugs and Pharmacy
Laws in India’,
Paramount
Law Publications Year 1987.
7)
Mehta, “Hand book of Drug Laws”, University
Book Agency, Allahabad.
8)
“Laws of Drugs
and Medicines”, Beotr Law Book Agency, Allhabad.
---------------------------------------------------------------------------------------------------
3.1(T)
THIRD
YEAR B. PHARM
PHARMAACOGNOSY-II (THEORY)
Minimum
50 Hrs/Yr
1.
Nature, occurrence,
chemistry, biogenesis, extraction, and
isolation of
the Classes of chemical
constitutents mentioned in (2) to (7). The systematic
Study
including biological
source, geographical sorce, morphology,Histology,
cultivation, collection
and preparation, active
constituents,Chemical tests,
substitutes and adulterants, therapeutic uses etc. of the
drugs Underlined in (2) to (7)
2.
Alkoloids:
Areca nuts, aconite roots, cinchona bark, stramonium
herb, hyoscymus herb, belladonna
herb, datura herb, coca leaves, tobacco leaves,lobelia
herb, pepper fruits, ephedra stems, opium, ipecac roots,
colchicum corms,
ergot, calabar
beans, nux-vomica seeds, rauwolfia roots,
jaborandi leaves,
veratrum roots, kurchi bark, vinca leaves, withania
roots, punarnava roots, pilocarpus leaves,
shankhapushpi.
(17)
3.
Volatile oils : terpentine
oil, mentha oil, peppermint oil, cinnamon bark,cassia
bark, umbelliferous fruits – fennel,
coriander, Indian dill, European
diil, anise, caraway,
cumin, orange&lemon peels, camphor, jatamansi roots,
banafsa leaves, buchu leaves,
clove buds, cardamom fruits, ocimum leaves,
valerian roots, garlic bulbs,
sassurea roots,
nutmeg seeds, mace of nutmeg,
acorus roots,
eucalyptus leaves, musk, chenopodium
oil, saffron.
(18)
4.
Miscellaneous: Pyrethrum flowers, mylabris,
cantharides.
(2)
5.
Enzymes: Their classification;Detailed study of papain,
malt extract, pepsin,bromelain,
trypsin, chymotrypsin & other pharmaceutically useful
enzymes & their applications.
(3)
6.
Coommercial fibres of vegetable, animal, mineral
& synthetic origin :
Cotton, hemp,
jute, flax, silk,
wool, regenerated fibres-rayon,
acetate rayon, nylon,
orlon, terylene,
polythene, asbestos, glass wool.
(3)
7.
Plant growth
regulators :
Auxins, gibberellins,
cytokinins acid
& others.
(3)
Application
of plant harmones.
8.
Introduction to Ayurvedic Pharmacy :
Brif account
of basic
principles of
ayurveda. Drugs & dosage forms of
ayurvedic medicines. Some aspects of
standardization of ayurvedic formulations.
(4)
---------------------------------------------------------------------
3.2
(P) THIRD YEAR B. PHARM
PHARMACOGNOSY-II
– (PRACTICALS)
Minimum 50 Hrs./Yr.
Practical
will be based upon the theory mentioned in the syllabus.
-
Study
of detailed histology including powder characteristics
of Nux-vomica, Coriander, clove,
Cardammom, Eucalyptus, Ginger.
-
Study
of detailed histology including powder characteristics
of Fennel,Coriander, Clove, Cardammom, Eucalyptus,
Ginger.
-
Identification
of adulterants in powdered crude druge by microscopy.
-
Identification
of fibres by microchemical tests.
-
Gross
morphological identification of drugs mentioned in
theory.
-
Extraction
if alkaloids and volatile oils.
-
Study
of the components of alkaloids & volatile oils by
TLC.
RECOMMENDED
BOOKS :
Latest
editions of the following books.
1)
Trease and Evans, pharmacognosy,
15th edition, W.B. Sounders Co. Ltd.
2)Wallis
T.E., Textbook of Pharmacognosy , CBS publishers &
Distributors.
3)
Shah C.S., and Quadri J.S., Textbook of
Pharmacognosy,
B.S.
Shah prakashan, Ahmedabad.
4)
Brady L.R., Tyler V.E., Robbers J.E., Pharmacognosy,
K.M.
Varghese Company.
5)
Kokate C.K., Purohit A.P.,Gokhale S.B., Textbook of
Pharmacognosy,Nirali Prakashan, pune.
6)
Turner T.D.& Brain K.R., Practical Evaluation
of Phytopharmaceuticals Wright-scientechnica, Bristol,
1975.
7)
kokate C.K., Practical
Pharmacognosy, Vallabh Prakashan, Delhi.
8) Khandelwal K.r, Practical Pharmacognosy, Nirali
Prakashan, Pune.
9)
Ayurvedic formulary of India, Part I & II,
Government of India, Ministry
of Health & Family Welfare.
10)
Wagner H., Bladt.S., and Zganiski E.M., Plant Drug
Analysis. – A
TLCAtlas translated by A.Scott., Springer Verlag,
Berlin, Hedelberg, N.Y. Tokyo.
--------------------------------------------------------------------------------
3.3(T)
THIRD YEAR B.PHARM
CLINICAL
PHARMACY & DRUG INTERACTIONS - (THEORY)
1.
Objective and scope of clinical pharmacy, present
status. Clinical pharmacy practice opportunities in
hospital and community pharmacy practice.
2.
Role of pharmacist in patient care in hospital from
time of admission to discharge and follow up, pharmacist
conducted patient interviews and presentation of
medication history. Patient drug profiles. Discharge
interview. Patients counseling and assessment of
compliance.
3.
Long term care facilities, care of neonates,
pediatric, genetric patients.
4.
Monitoring the patients in health and illness.
Monityoring of patients with chronic diseases.
Therapeutics drug mentoring, using clinical
phyarmacokinetics for dosages individualization.
5.
Advanced drug re4action reaction, Factors
predisposing ADR’s, different manifestations, detection
and repotating.
6.
Drug Interactions, mechanisms, pharmacokinetic and
pharmadcodunamic interaction, examples, interactions of
drug with food, alcohol, and tobacco and during pregnancy.
Clinical significance and evolution.
7.
Drug interference with diagnostic test, physical,
clinical and biological significance of selected
pathological test.
8.
Intravenous admixtures, preparations
andadministration Incompatibilities in I.V. admixtures,
totaln parenteral nutrition.
9.
Drug Information Services and Centres, activites,
elements of drug literature utilization, selection,
evalutions and communication, absratcing services,
computer applications.
10.
Investigational drug and clinical research phases,
pharmacist’s role in clinical trials, stastistical
methods of interpretation, legal and ethical
considerations.
11.
Prevention of Drug abuse and Drug Toxicity.
12.
Essential Drug & Drug use.
RECOMMENDED
BOOKS :
Latest
editions of the following books.
1.
Blissit
C.W., Webbol, Stanaszek W.F(Editors) Clinical P0harmacy
Practice., Lea &
Febiger, Philadelphia, 1972
2.
Haliltion,
Preceptives in Clinical Pharmacy Ed. (Whitney),Drug
Intelligience Publications.
3.
Kabat
Hugh and Leaf Febriger Clinical Pharmacy Handbook.
4.
Lawson
& Richards, Clinical Pharmacy & Hospital Drug
Management by Chapman & Halls Publications Year 1982.
5.
E.V.
Klejiin & Jonders J.R.,
‘Clinical Pharmacy’ & E
lsevier /North Holldand Biomedical Press New York
1977.
6.
Herfindal
E.T.Hirschman. J.L., ‘Clinical Pharmacy and
Therapeutics’ and The Williams and Willkins Company
Baltimore 1977.
7.
‘Hanstens’
Text books of Drug interactions, Clinical significance of
Drug- Drug interactions 5th editions
Philadeiphia Lea and Bajaja A.N. Febiger 1985.
8.
‘Clinical
Pharmacy’ Dr .Tipnis , H.P. Careed Publications 2003.
--------------------------------------------------------------------------------
THIRD
YEAR B. PHARM
PHARMACOLOGY
–I (THEORY)
1.
The
need for Therapeutic Intervention
A)
Therapeutic modalities : i)Surgery, ii)Radiations,
iii)Genetic
iv)Immunological v) Pharmacological
B)
Parmacacotherpy: i) Therapeutic goals, ii) Rationa desing
iii) Use of drugs
2.
Descriptive Pharmaclkinetics :
A)
Absorption/Administration:
a)
Alimentary canal :
i) Entral, Oral mucosa :
sublingual, buckle, rectal mucosa
b)
Injection (parenteral)
c)
Pulmonary
d)
Integumentary: i) Topical, ii) Transdermal
iii) Intraocular
e)
Other routes of administration
f)
Merits and demerits of various routes
g)
Mechanism of absorpition into vascular or
lymphatics system
B)
Distribution:
a)
Factors influencing drug distribution.
b)
Volume of distribution.
c)
Binding of drug to plasma proteins
d)
Selective accumulation of drugs.
e)
Physiological barriers to drug distribution viz,
blood brain barrier blood CSF
Barrier and placental barrier
C)
Biotranformation of drug:
a)
Pathways of drug metabolism.
b)
Inhibition and induction of drug metabolism.
c)
Factors affecting drug metabolism.
D)
Excretion of drug:
a)
Renal, fecal, biliary and pulmonary excretion of
drugs.
b)
Excretion through other body fluids.
3.
Pharmacodynamics :
a)
Quantitative aspects of drug action and receptors.
b)
Enzyme selectivity.
c)
Quantitative aspects of drug action.
d)
Drug response, potency, therapeutic efficacy and
tolerance.
Factors
modifying the effect of the drug:
a)
Age
b)
Pharmacogenetics,
c)
Drug resistence,
d)
Drug allergy,
e)
Drug tolerance
4.
Autocoids:
a)
Histamine and histamine antagonist
b)
Serotonin and serotonin antagonist
c)
Kinins, and angiotensin
d)
Lipid derived autocoids; Prostglandins, lekotriens
and platelet activating factor.
5. Anti-
inflammatory drug: NSAID drug used in the treatment of
musculo skeletal disorders:
Rheumatoid arthritis, osteoarthritis, and gout.
6.
Drug used for Cough and Asthma
7.
Drug acting on Endocrine system
Hypothalamic and pituitary
hormones,
Thyroid and antithyroid drug
Adrenocorticosteroids and
adrenocortical antagonist
Gonadal hormone and
inhibitors,
Pancreatic hormones
Antidiabetic drugs
Parthyroid hormones
7.
Drug used in Gastrointestinal system
Hyperacidity
and petic ulcer.
Emetic,
antimetics, laxatives and antidiarrhoeals
Drugs
for inflammatory bowel diseases.
8.
Drug acting on the Central Nervous system :
General
anesthetics and local anewsthetics
Sedatives
hypnotics and anxiolytics
Drugs
used in psychiartric disorders.
CNS
stimulants
Antiepileptics
Skeletal
muscle relaxants
Opioid
analgesics and antagonist
Anthipyretics
Drugs
used for Parkinsonism and other neuro degenerative
disorders
Drug
for cognitive dysfunction.
-----------------------------------------------------------------
THIRD
YEAR B. PHARM
PHARMACOLOGY
– I (PRACTICAL)
1)
Effect of Acetycholine on frof rectus abdominus
muscle preparation
2)
Dose response curve of acetycholine using
frog rectus abdominus muscle.
3)
Dose responmse curve of histamine using guinea pig
ileum.
4)
Efeect of acetycholine on rat intestine
5)
Competitive antagonism between acetylcholine and
atropine on guinea pig ileum
6)
Competitve atagonis betwwn hiistqamine and
diphenyhedramine on guinea pig ileum
7)
Effect on adrenaline and acetycholine on frog’s
heart preparation.
8)
Effect of adrenaline and acetylcholine on frog ‘
s heart preparation
9) Effect
of atropine on acetycholine and potassium induced
responses using perfused Frog
heart
10) Effect of adrenergic and cholinergic drugs on mean blood
pressure, heart rate,Respiratory rate of dog.
11) Effect of myotics and
mydriatics on rabbit’s eye
12) Demonstration
of rout
RECOMMENDED
BOOKS
1
Tripathi K.D., Essentials of Medical pharmacology
published by jaypee brothers, New
Delhi, India 4TH
edition, 1999.
2
Sheth S.D., Tetbook of pharmacology, published by
Churchill Livingstone PVT.LTD,New Delhi, India, 2nd
edition, 1999.
3
Goodman and Gilman, the pharmacological basis of
theapeutics published by Mc
Grow- Hill, Intenational
edition New York U.S.A, 9th edition, 1999.
4 Satoskar R.S., Bhandarkar S.D Ainapure S.S
pharmacology and pharmacotherapeuics,Published by popular
prakashan, Mumbai, India, 18th editon, 2003
5
Wilson and Gisvild’s Textbook of organic, medicinal and
pharmacological 10th edition,1998
---------------------------------------------------------------------------
THIRD
YEAR B. PHARM
PHARMACEUTICAL
ANALYSIS- II (THORY)
1.) General Principal of Spectoroscopy:
Wave- prtical dulity, wave
properties, particulate properties, line spectrum abnd
spectrum,Absorpation spectroscopy, emission spectroscopy,
electromagnetic spectrum, meaning of
various Terms like
absorbance, transmittance, absorptivity, mjolar absorpity,
and E1cm 1% and y max ‘effect Of
solvent and pH ymax’
2.)
Ultraviolet-
Visible
Spectoscopy:
Beer- Lambert’s law,
its derivation, in Beer’s law, various electronic
transition, auxochromes,Auxochromic
effect bathochromic and hyposchromic shifts.
Instrumatation with monochromators –
prisms and grating, filters-absorpition and
interface, detectors- Barrier cell, photo cell,
photomultiplier tube
,refractive index dectector, single and double beam UV
spectrometer Apllications
of UV spectroscopy. Problems based on Beer Lambert’s
law, trasmittance, Absorbance etc.
3).Infrared
Spectroscopy:
Principle, starching and
bending vibrations, instrumention, sample preparation
techniques.
Applications, various regions I IR spectrum and
their use for characterizing of funcational groups.
Problems based on functional groups
characteratization and structure elucidation based on wave Numbers.
4)
Nuclesar
Magnectic Resonaces (NMR) Spectroscopy
Principle, nucleat spin and
quantum numbers, magnetogyric constant, radio- frequency.
Flipping of the nucleus, chemical
shift ,Standered used I NMR spectroscopy- TMS, magnetic
shieldin Constant.Fine structure of NMR spectrum-
multiplyicity of peaks, coupling constant relaxation
Processes solvents used, intstumention, ssaturation
and ringing efeect. Application.
5)
Spectrofuorimetry :
Principle, definition and types of luminescences.
Resonaces fluorescences and Stock’s effect.
Mechanism of fluresecences and phoshorescenc34s,
singlet and triplet states, quenching of
Fluorescences, factrors affecting fluorescences,
structure of a molecdulele and fluorescence,Instrumention
and application.
6).Flame
Photometry/Automic Absorption Spectoscopt:
Principle, flam absorption,
emission and florescence spectroscopy. Fuels and oxidqntsw,
detail Explanation of transitions involved jb flam spectroscopy of Na
metal, Mg +1 ion and A1 +2 ions.Explanation
of singlet, doublet and triplet states. Temperature
profiles, flame absorption and flamemission profiles.
Atomizers and burners, non-flame atomizers. Applications.
7)
Polarography :
Principle instruments-
dropping mercury elecftode. Saturated clomle electrode,
liquid- liquid Junction
postential, ploarographic cellt. Explanation of origion of
S-shape C-V curve. Ilkovic
Equation (no derivation) –
imperotance of factors in it. Applications
Amperometric titrations - principles, differents
type, instruments and application.
8.)
Mass Spectroscopy:
Principle, instruments- Single and double focusing
mass spectrometer.Magnetic field delection,Electronic
field deflection Time of flight, m/z ration and its
derviation, fragmentations,Rearrangement and applications.
9).Nephelometry
and Turbidimetry:
Principle, Tyndall effect, Dubosque tribidemeter
and E
eel’s nephelometer.
10)
Chromatography:
Principle,
liner elution ehromatography, different kinds of
chromatographic te4chniquies.Theories of chromatography :-
plate andrate theory. Optimization of cloum parameters-
column Efficiency,
selectivity factors & capacity factor. Van Deemeter
equation (No derivation)and
Factors responsible for band broadening.
Merthodology and applicfation of adsorption, partition
Ion- exchange and gel chromatography.
HPCL-
Principle, instrumention, qualitative and quantitative
estimation normalization technique,Internal and external
standard, application TLC Principle,
various ways ofg development using mobile phase, locating
compounds using Mobile
phase, locating compounds using various methods,
identifications of compounds
On plates from R, values and other method.
General
application.
Paper
Chromatography – Principle,
Methodology and applications.
-------------------------------------------------------------------------
THIRD
YEAR B. PHARM
PHARM.
ANALYSIS – II (PRACTICALS)
1.)
Experiments based on U.V.Spectoscopy,5-7
different types of formulations such as tablets,Injections
capsules, suspensions, gel etc.
2)
Indometri titrations:
Resocrnionla, Methyl
parben, Isoniazed (Tablets)
3) Iodimetry:
Analgin (tablets), ascorbic
acid (powder and tablets)
4) EDTA titrations:
Milk of Magnesia, Aluminium hydroxide (gel and
tablets) ,
Calcium gluconate
(injection), Mercuric chloride.
5)
Acid- base titrations:
Milk of Magnesi, Borax and
boric acid mixture, Borax and Na2Co3,
mixture orthoshoric acid.
6)
Chromatography – Detemination of ion – exchange
capacity of reins.
7)
Iodate
titrations : Ascorbic
acid (power ) , weak iodine solution
8)
Argentimetry:
Thiourea, sodium chloride, Ammonium chloride.
9)
Cerimetry: paracetamol
(Tablets), ferrous gluconate (injection, tablets) .
10)
Permanganate
titrations: Hydrogen peroxide (solution), calcium
gluconate (tablets).
RECOMMENDED
BOOKS:
Latest
editions of the following books
1)
Beckett, A.H AND Stenlake J.B., practical pharmaceutical
Chemistry,part I& II , Athlone press, London
2)
K.A.Conners, A Textbook of pharmaceutical Analysis, john
Wiley & sons, new york, U.S.A.
3)
Skoog, Holler, Niemen, Eds, priciples of Instrumentl
Analysis, Harcourt publishers, U.S.A
4)
A I. Vogel, Qualitative Inorganic Analysis, Longman Group,
London
5)
John R. Iyer, Applications of Absorpation spectroscopy of
organic compounds, Englewood, U.S.A
6)
R.M. Silverstein, spectrometric Identification of organic
compounds, john wiley &sons, Inc., New York, U.S.A
------------------------------------------------------------------------
THERD
YEARB. PHARM
DISPENSING
AND HOSPITAL PHARMCY (THEORY)
PART-I:
Dispensing pharmacy:
1
pharmaceutical Arithmatic: Different systems of weights
and measues calculation of doses,Percentage
solution, allegations, proof strengths, dilution and
concentration of solutions, solids and
Alcohol
2
principles of dispensing and prescription handling,
prescriptions, description, various parts of a
Prescription refills,
prescription pricing.
3
posology: factors affecting dosage, pediatric doses,
calculation of doses for renally impaired
Patients
4
powders: Importance, simple powders, methods of weighing
wrapping, packaging of powders
Containing volatile, hygroscopic, vegetable
extracts, potent substances, liquefying substsaline Substances and explosive mixtures. Compound powders, bulk,
powders, Effervescent powders and
Granules. Tablet triturates.
5
Mixtures: Definition, importance, classification,
vehicles, dispensing of mixtures.
6
Incompatibility: Definition various types, chemical,
physical or therapeutic. Intentional and
Unintentional, tolerated and adjusted
incompatibility.
i) Inorganic
incompatibilities including those of metals and thir
salts, non metals, acids, alkalies.
ii) Organic incompatibilities
including acids, alkaloids, barbiturates, tannins,
quaternary ammonium Compound,
correction of incompatibilitese.
7
pills: Definition, advantages disadvantages essential
reqirements of a good pill. Preparation, excipients and
coting. Pills containing small doses of oxidizing
substances extract and water soluble drugs.
8
pastilles; Bases and Moulds.
9
Lozenges: Base and apparatus for preparation.
10
ENTpreparation: Ear drops, nasal drops, mouth washes,
gargles, throat paints
Part
–ii Hospital pharmacy:
1
Definition, development and administration of the hospital
pharmacy department.
2
Organization and administration of Hospital, pharmacy and
Therapeutics Committee : personnel.
Location of the phamacy unit in relation to other
hospital departments, space and physical plant
Requirements in relation to the size of hospital
3
purchase and supply: Inventiry control policy and
procedure of purchase of drugs, storage of
Drugs,
4
Manufacturing in hospital pharmcy: Bulk compounding and
pre –packaging.
5
Drug distribution systems in the hospital: Floor stock
systems, inpatient and control procedures, dispensing of
ancillary supplies, controlled substances: emergency
6
Hospital formulary, pharmacy procedural Manual and its
preparation
7
Central supply service departments: Its location plan and
activities.
8
Sterilization and quality control testing of
surgical dressing, instruments, syringes and needles,
rubber gloves andd cathers, tubings, utensils, mattresses,
and other surgical products.
9
Infection control in hospitals: Nosocomial infection
10
safe use of medications in the hospitals, medication
errors and safety practices.
------------------------------------------------------------------------
THIRD
YEAR B. PHARM
DISPENSING
AND HOSPITAL PHARMCY (PRACTICALS)
Part
I : Dispensing pharmacy :
i)
Latin terms and abbreviations
ii)
Different types of mixtures including the
following. Simple mixtures Mixtures containing diffusible
solids Indiffusible solids precipitate forming substances,
Effervescent mixtures slightly soluble substances.
iii)
Emulsions containing different proportions of oil ,
water and gums. Emulsion contating insoluble substances,
iv)
Powders : Simple powders, containing Volatile ,
hygroscopic substances, Vegetable extracts, potent
substances, Liquefying substances, Effervescent powders,
compound poders, Bulk powders
v)
Tablet triturates and displacement value
calculation.
vi)
Pills
: Copper sulphate & phenolphthalein
vii)
Lozenges : Bismuth carbonate, Glycyrrhizin
viii)
Pastilles : Menthol A mmonium Chloride
ix)
Miscellaneous preparatios : Insufflations
Inhalation M outhwash Gargles
x)
Incompatibilies in mixtures, correction theof and
mixtures containing incompatibility related to acid
alkaloids, tannins, quaternary ammonium compounds.
Part
ii : Hospital pharmacy
1)
Bulk compounding
i) Sodium,
salicylate mixture – KEM Hospital formulary.
ii)
Outpatient Electrolyte pediatric Mixture (Extrapharmacopoeia)
iii)
Oral Dehydration solution –WHO
1)
Preparation and monographic evaluation of pediatric
chalk mixture BPC.
2)
Monographic evaluation of
i)Absorbent cotton wool (I P)
ii) Absorbent cotton Gauze (B P)
3)
Preparation of surgical supplies, Eyeswabsticks,
cottonbuds. Eye swabs, Gamgeepads theatre gauze, roller
gauze ward gauze etc
4)
Preparation of anticoagulant solution (IP)
5)
Preparation of dialysis solution : i) Intraperitoneal
Dialysis solution (I P)
ii)Haemodialysis solution (B P)
6)
Preparation of anticoagulant bulb (KEM Hospital
formulary )
7)
Pre parathion of transfusion fluids and electrolyte
replenisher solutions, Calculations, of milliequivalent
concentrations of salts and conversion in to percentage
conc.
8)
Miscellaneous preparatios commonly ued in Hospital
pharmcy such as i)Lubricating
jelly. Ii)
starch enema iii) Neurological solution
9)Demonstration
of IV admixture incompatibity in parenteral fluids like
diazepam injection and Dextrose saline nsolution
10)
Patient case presentation
11)
Computer application in Hospital pharmacy
12)
Hospital visits.
RECOMMENDED
BOOKS:
Latest
edition of the following books
1.
Copper & Gunn’s ‘Dispensing for
pharmaceutical students ‘Ed. Cartr, pitman Medical, CBS publishrs, 12th
edition, 1975.
1
‘Husa‘s pharmaceutical Dispnsing ‘Ed Martin
(Mac publicating. )
2
Sperowl
“prescription pharmacy ‘. J.B Lippincott. 2nd
edition 1970.
3
‘Remington’s
pharmaceutical sciences -20th edition Year
2000. Martin (Mac publication )
4
W.F Hassan, ‘Hospital pharmacy,’ 5th
edition 1986. Lea & Fedibiger publications.
5
M C Allwood & J. T fell Blakwell “Textbook of
Hospital pharmacy “scientific publications Oxford London
1980.
6
J.J perkins “ principles and Methods of
sterilization in Helth sciencences charles Thomas
publication
7
Kennenth & Michael j. Aberson ‘sterial
preparans for the hospital for the hospital pharmacists
and procedures ‘ ANN Arbor science publisher.
8
Hospital acquired infecation: Guidelines to
laboratory methods, WHO regional publications: European
seris NO 4 WHO.
------------------------------------------------------------------------
THIRD
YEAR B. PHARM
PHARMACEUTICAL
CHEMISTRY –III (THEORY)
Study
of the following classes ofr drugs with respect to
classification , physico-chemical propertics mode of
action strure activity relationship and synthesis of few
important drugs :
1
sedatives and hypnotics: Amobarbital *, pentobarbital*, Phenobarbital *, gluthetimide
*, trichoroethanol , chloral hydrate *,oxazepam.
2
psychotropic drugs :
Neuroleptics, anti –anxiety agents. Diazepam,
1-4- benzodiaepin -4- oxides, chlorpromazine*, haloperidol.
*
3
Antiepileptic agents. Mephenytion, phensuximide, phenytion *, headstones,
succinimides *.
4
Hypoglycemic agents: (or Antidiabetic agents)
Chlorpropamide * , Metformin HCI , tobutamide* , Glyburide.
5
Thyroid and Antithyroid agents.
6
Antiallergic agents (or Antihistaminic agents)
Chlorphenirmire *, diphydramine *, mepyramine *,
prometidine *.
7
Antiulcer agents: Ranitidine, Cimetidine *
8
Diuretics: Chlorothizide *, hydrochlorthiazide *,
acetazolamide, furosemide *, chlorthlidone, Etharynic acid
*
9
Anticancer Agents : Carboplatin, cisplatin.
10
Corticosteroids and anti inflammatory sterods
11
sex steroids , anabolic steroids and their
antagonists , testosterone *, estradiol *, estrone *,
progesterone *,
12
Oral contraceptives : DES*, Hexestrol*
------------------------------------------------------------------------------------------
THERD
YEAR B. PHARM
PHARMACETICAL
CHEMISTRY – III (PRETICALS)
I]
Recrystllization of Organic Compounds
II]
Organic separation and analysis of mixtures containing two
compounds. Some of the following combinations can be
analysed.
A)
Strong acid +neutral
Strong
base + neutrl
Strong acide + weak acid
Weak acid + base
Weak acid + neutral
B)
Solid + solid
Solid + Liquid
Liqud (non –volatile) +
Liquid (non –volatile)
Liquid + Liquid
Watersoluble solids
Eutectic mixtures
III]
Synthesis of some of the following compounds:
i)
2-napthyl benzoate
ii)
Cyclohexanone from cyclohexanol
iii)
1-pheny -2- azonapthol
iv)
Methyl salicylate
v)
Aspririn
vi)
S-Methyl thiourea
RECOMMENDED
BOOKS:
Latest
editions of the following books.
1)
Foye, W.O principles of Medcinal chemistry, K.E. Varghese
and Company, Mumbai -31, fourth Edition, 1999.
2)
Wilson, C Gisvold, O., and Doerge, J. B.Textbook of
Organic Medicinal and pharmaceutical Chemistry, J.B.
Lippincot Company, TOront, Tenth Edition.
3)
Burger, A.B. Part I, II and III MedicinalChemistry,
john Wiley & Sons. Inc. New york.
------------------------------------------------------------------------
THIRD
YEAR B. PHARM
PHARMACEUTICS
–III (THEORY)
1)
Parenteral products, product Development, formulation
factors, vehicles and additives adjustment of isotonicity,
containers and closures, production facilies, aseptic
processing, environmental controls, air handing systems,
sterilization prosesses, equipment employed and quality
control.
2)
Ophthalmic products: Ocular absorption eye drops, lotins,
and ointments formulation additives and vehicles there of
production, packaging and quality control, contect lens
solution.
3)
Blood products: Historical background, collection and
storage of blood whol humen blood fraction of plasma and
monographs of different plasma fraction, Quality control
of blood products and anticoagulant solutions, plasma
Volume Expanders.
4)
Surgical Dressing, Fibres and Fabric, plasters, Sutures
and Ligatures of different types. Preparation and Quality
control testing.
5)
Coating of solid dosage forms: principles, processes and
equipment involved in the coting of granules, tablets and
capsules with sugar, film formers and enteric materials.
Aqueous film coating and quality control of coated dosage
forms.
6)
Radiopharmaceuticals: Radioisotope Generators,
formulation, application, handling and quality
7)
Packaging of pharmaceutical products: Containers and
Closures, requirements and quality control of packaging
materials used in pharmaceutical packaging including
glass, plastics, paper, paperboard, metals, and ancillary
material, Labels & Labeling. Products package
compatibility. Introduction to machines used in packaging,
strip, blister, and FFS packaging.
---------------------------------------------------------------------------
THIRD
YEAR B. PHARM
PHARMACEUTICS
–III (PRACTICALS)
A]
INJECTION:
1)
Monograph on injection,
2)
Filling & sealing of ampoules
3)
Large Volume parententerals
4)
Sodium Chloride injection
5)
Dextrose injection
6)
Compound sodium lactate injection. Small volume
parenterals
7)
Adrenaline tartarate injection.
8)
Emetine injection
9)
Calcium gluconate injection
10)
Ascorbic acid injection
11)
Morphine Injection
12)
Digoxin injection
13)
Riboflavine injection
14)
Ethanolamine oleate injection
15)
Trisodium edentate injection
B]
Aseptic
processing of parenterals
16)
Textracyline injection
17)
Thiacyline injection
18)
Cortisone acetate injection
Oily
Injection
19)
Test for oily vehicles.
20)
Oily phenol injection.
21)
Calciferol injection
22)
Deoxycortisone acetate injection
DISSOLUTION
TEST FOR TABLETS:
23)
Dissolution test for ibuprofen tablet.
24)
Dissolution test for tolbutamide tablet.
C)
FILM COATING OF TABLETS:
25)
Coating of tablets using enteric polymers.
26)
Coating of tablets using non – enteric polymers.
27)
Disintegration test of enteric coated tablets.
D)
OPTHALMIC PREPATIONS: Eye drops.
28)
Chloramphenicol eye drops.
29)
Atropine sulphate eye drops
30)
Hypromellose eye drops.
31)
Pilocarpine hydrochloride eye drops
32)
Prednisolone eye drops.
33)
Homatropine eye drops
34)
Zinc sulphate & adrenaline eye drops.
35)
Sulphacetamide eye drops.
36)
Physostigmine eye drops.
37)
Phenylephrine eye drops
Ophthalmic
Suspension
38)
Dexamethasons ophthalmic suspension
39)
Tetracycline ophthalmic suspension
40)
Hydrocortisons acetate and Neomycin sulphate ophthalmic
suspension .
Eye
Ointement
1)
Atropine Sulphate eye ointment
2)
Tetracycline eye ointment
3)
Mercuric oxide eye ointment
4)
Sulphacetamide eye ointment
Eye
Lotion
5)
Zinc sulphate eye lotio
6)
Sodium Choloride eye lotion
Contact
Lens Solution
7)
Wetting splution for hard conteact lens
8)
Soaking and cleansing solution for hard contact lens
9)
Cushioning solution for soft contact lens
E)
TESTING OF PACKAGING MATERIALS
10)
Testfor hydrolytic Resistance of Glass I.P
11)
Rubber closure for container for Injection preparation .I.P
12)
Test on plastic container I.P
13)
Test on paper, paper board and demonstration of packaging
machine.
F)
STERILITY TESTING OF INJECTION AND OPHTHALMIC
PREPATIONS.
PREPARATION
RECOMMENDED
BOOKS:
Latest
editions of the following books.
1.
L. Lachman H. Liberman, J. Kanig, ‘The Theory and
practice of Industrial pharmacy’, Varghese publishing
House, Mumbai
2.
E.A Rawlins, Bentley’s Tetbook of pharmaceutics, All
India Traveller BOOK Seller, Delhi.
3.
Remingoton’s pharmaceutical sciences, Osmol Mack publishers, Pennsylvania,
4
M.E. Aulton, ‘pharmaceutics – The Science of Dosage
from design’, Churchill Livingston, London, 1st
Edition, 1988.
5
S.J Cater, ‘Cooper and Gunn’s Dispnsing for
pharmaceutical students,’ CBS publishers and
Distributors, Delhi.
6
K.E.Avis, L.Lachman, H.A Lacman, H.A. Lieberman,
‘pharmaceutical Dosage Forms – parenteral
Medication’, Vol.1, Marcel Dekker Inc,’ New York
7
Indian pharmacopia, 1996.
8
British pharmacopia, 2002
9
United states pharmacopia, 2000
10
British pharmaceutical Codex, 1973.
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